Drugs can make you do wild, unpredictable things. But even the wildest party animals in the 1980s could never imagine the kind of drug-fueled spree the titular critter of Cocaine Bear goes on. After a drug smuggler dumps bags of cocaine in a forest in Georgia, an American black bear ingests some of that coke and begins to go on a rampage in the area. As this happens, a slew of wildly different people converge on the forest. Nurse Sari (Keri Russell) is heading to the forest to look for her daughter, Dee Dee (Brooklynn Prince). Drug kingpin Syd Dentwood (Ray Liotta), who has a vested interest in seeing the cocaine retrieved, sends his son Eddie (Alden Ehrenreich) and loyal cohort Daveed (O’Shea Jackson Jr.) to get the drugs back. These are just a few of the lives that are about crash right into the cocaine bear, who has an increased hankering for human flesh now that all the powder is in her system.